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Article

TGFβ-activated kinase-1 knockdown in hematopoietic stem-progenitor cells causes PANoptosis and myelodysplastic syndrome-like disease in mice.

Haematologica - 1 Apr 2026

Zhang Lei, Li Wenyan, Thalla Rohit, Ma Rongyao, Mack Ryan, Kini Ameet R, Runde Austin, Hagen Patrick A, Barton Kevin, Kosti-Schwartz Jorgena, Breslin Peter, Ji Hong-Long, Zhang Jiwang

Abstract excerpt

Mutant SF3B1 (SF3B1mut) in hematopoietic stem/progenitor cells (HSPC) primarily affects erythropoiesis, resulting in myelodysplastic syndromes (MDS) with refractory macrocytic anemia and ring sideroblasts. SF3B1mut results in aberrant splicing of a large number of transcripts in HSPC due to the alternative use of cryptic splice sites. Aberrant splicing of Tmem14c and Abcb7 has been shown to be the cause of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41163575
DOI: 10.3324/haematol.2025.287951
PMCID: PMC13040159

Genes

RIPK1
SF3B1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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TGFβ-activated kinase-1 knockdown in hematopoietic stem-progenitor cells causes PANoptosis and myelodysplastic syndrome-like disease in mice.PMID 41163575Read ↗

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