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Article

Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A.

Nature medicine - 1 Aug 2003

Hrachovinová Ingrid, Cambien Beatrice, Hafezi-Moghadam Ali, Kappelmayer János, Camphausen Raymond T, Widom Angela, Xia Lijun, Kazazian Haig H, Schaub Robert G, McEver Rodger P, Wagner Denisa D

Abstract excerpt

High plasma levels of soluble P-selectin are associated with thrombotic disorders and may predict future cardiovascular events. Mice with high levels of soluble P-selectin have more microparticles in their plasma than do normal mice. Here we show that chimeras of P-selectin and immunoglobulin (P-sel-Ig) induced formation of procoagulant microparticles in human blood through P-selectin glycoprotein ligand-1...

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Identifiers

PMID: 12858167
DOI: 10.1038/nm899

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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