Article
Interaction of P-selectin and PSGL-1 generates microparticles that correct hemostasis in a mouse model of hemophilia A.
Nature medicine - 1 Aug 2003
Hrachovinová Ingrid, Cambien Beatrice, Hafezi-Moghadam Ali, Kappelmayer János, Camphausen Raymond T, Widom Angela, Xia Lijun, Kazazian Haig H, Schaub Robert G, McEver Rodger P, Wagner Denisa D
Abstract excerpt
High plasma levels of soluble P-selectin are associated with thrombotic disorders and may predict future cardiovascular events. Mice with high levels of soluble P-selectin have more microparticles in their plasma than do normal mice. Here we show that chimeras of P-selectin and immunoglobulin (P-...
Topics
- Adult
- Animals
- Blood Coagulation
- Disease Models, Animal
- Factor VIII
- Hemophilia A
- Hemostasis
- Humans
- Immunoglobulins
- Membrane Glycoproteins
- Mice
- Mice, Knockout
- Middle Aged
- P-Selectin
- Phenotype