Article

Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferation

2014-03-19

Abstract excerpt

Thrombopoietin (TPO) acting via its receptor Mpl is the major cytokine regulator of platelet number. To precisely define the role of specific hematopoietic cells in TPO dependent hematopoiesis, we generated mice that express the Mpl receptor normally on stem/progenitor cells but lack expression on megakaryocytes and platelets ( Mpl PF4cre/PF4cre ). Mpl PF4cre/PF4cre mice displayed profound megakaryocytosis and t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 93550322-876d-54f9-a98c-1e7d4bf720aa
DOI: 10.1101/003459

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mpl expression on megakaryocytes and platelets is dispensable for thrombopoiesis but essential to prevent myeloproliferationDOI 10.1101/003459Read

Hematopoietic Deficiencies in c‐mpl and TPO Knockout MiceSemantic proximity Read

Physiological regulation of early and late stages of megakaryocytopoiesis by thrombopoietin.Semantic proximity Read

Deficiencies in progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the thrombopoietic receptor c-MplSemantic proximity Read

Thrombopoietin: the Primary Regulator of Megakaryocyte and Platelet ProductionSemantic proximity Read

Determinants of platelet number and regulation of thrombopoiesisSemantic proximity Read

The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasmSemantic proximity Read

The residual megakaryocyte and platelet production in c-mpl-deficient mice is not dependent on the actions of interleukin-6, interleukin-11, or leukemia inhibitory factor.Semantic proximity Read

Mathematical modelling of megakaryopoiesis in Mpl-deficient and continuously thrombopoietin-stimulated mice points to an unknown control mechanismSemantic proximity Read

Insights into Regulatory Factors in Megakaryocyte Development and Function: Basic Mechanisms and Potential TargetsSemantic proximity Read

The molecular mechanisms that control thrombopoiesisSemantic proximity Read

Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor–related protein 1 (LRP1) on megakaryocytesSemantic proximity Read

Thrombocytosis.Semantic proximity Read