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Article

Inflammation fuels bone marrow exhaustion caused by Samd9l mutation.

The Journal of clinical investigation - 1 Nov 2022

Jung Moonjung

Abstract excerpt

Sterile α motif domain-containing 9 (SAMD9) and SAMD9-like (SAMD9L) syndromes are inherited bone marrow failure syndromes known for their frequent development of myelodysplastic syndrome with monosomy 7. In this issue of the JCI, Abdelhamed, Thomas, et al. report a mouse model with a hematopoietic cell-specific heterozygous Samd9l mutation knockin. This mouse model resembles human disease in many ways, including...

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Identifiers

PMID: 36317635
DOI: 10.1172/JCI164136
PMCID: PMC9621124

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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