Article
Integrated multiomic profiling reveals 2 distinct splenic marginal zone lymphoma subgroups with prognostic relevance.
Blood advances - 28 Jul 2026
Parker Helen, Mirandari Amatta, Stevens Benjamin, Oquendo Carolina Jaramillo, Duran-Ferrer Martí, Buermann Lara, Amarasinghe Harindra E, Thomas Jaya, Carr Louise, Syeda Shama, Sakthipakan Methusha, Parry Marina, Rose-Zerilli Matthew J J, Davis Zadie, McIver-Brown Neil, Xochelli Aliki, Ennis Sarah, Scarfò Lydia, Ghia Paolo, Kalpadakis Christina, Pangalis Gerassimos, Rossi Davide, Gaidano Gianluca, Wagner Simon, Ahearne Matthew, Seifert Marc, Plass Christoph, Weichenhan Dieter, Kimby Eva, Sutton Lesley-Ann, Rosenquist Richard, Amini Rose-Marie, Ljungström Viktor, Pratt Guy, Forconi Francesco, Stamatopoulos Kostas, Salido Marta, Ferrer Ana, Thieblemont Catherine, Hilton Laura, Morin Ryan, Walewska Renata, Martín-Subero José Ignacio, Oscier David, Oakes Christopher, Gibson Jane, Bryant Dean, Strefford Jonathan C
Abstract excerpt
ABSTRACT: Splenic marginal zone lymphoma (SMZL) is a rare B-cell malignancy with notable genetic, epigenetic, and clinical heterogeneity. In this study, we used coding and noncoding sequencing (n = 74), including whole-genome sequencing (WGS) of 24 paired tumor-normal samples, targeted sequencing (n = 55), and DNA methylation in 126 patients to characterize the disease. From WGS, we identified recurrent,...
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