Article
A conserved linkage group on chromosome 6, the 8.1 ancestral haplotype, is a predisposing factor of chronic rhinosinusitis associated with nasal polyposis in aspirin-sensitive Hungarians.
Human immunology - 1 Nov 2015
Szabó Kornélia, Polyánka Hilda, Kiricsi Ágnes, Révész Mónika, Vóna Ida, Szabó Zsolt, Bella Zsolt, Kadocsa Edit, Kemény Lajos, Széll Márta, Hirschberg Andor
Abstract excerpt
Inflammation plays a central role in the pathogenesis of chronic rhinosinusitis (CRS), and TNFα is a key pro-inflammatory cytokine in the pathogenesis of this disease. In our previous studies, we showed that the TNFA -308A allele is a genetic predisposition factor in a subgroup of aspirin-sensitive (ASA+) CRS patients suffering from nasal polyps (NP) in the Hungarian population. To determine whether the TNF -308A...
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