Article
The -308 G>A SNP of TNFA is a factor predisposing to chronic rhinosinusitis associated with nasal polyposis in aspirin-sensitive Hungarian individuals: conclusions of a genetic study with multiple stratifications.
International immunology - 1 Jun 2013
Szabó Kornélia, Kiricsi Ágnes, Révész Mónika, Vóna Ida, Szabó Zsolt, Bella Zsolt, Polyánka Hilda, Kadocsa Edit, Kemény Lajos, Széll Márta, Hirschberg Andor
Abstract excerpt
Single nucleotide polymorphisms (SNPs) of the tumour necrosis factor alpha (TNFα) gene (TNFA) have been extensively studied and shown to be associated with an increased risk of the development of various chronic inflammatory diseases. Inflammation has been demonstrated to play a central role in the pathogenesis of chronic rhinosinusitis (CRS), and TNFα is a key pro-inflammatory cytokine with important functions...
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