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Article

The 8.1 ancestral MHC haplotype is strongly associated with colorectal cancer risk.

International journal of cancer - 15 Oct 2007

Tóth Eva Katalin, Kocsis Judit, Madaras Balázs, Bíró Adrienn, Pocsai Zsuzsa, Fust George, Blaskó Bernadett, Karádi István, Adány Róza, Laki Judit

Abstract excerpt

Many recent data indicate that some alleles encoded in the central major histocompatibility complex (MHC) region (Class III) of short arm of chromosome 6 may modify the risk of cancer development. Therefore we determined 4 single nucleotide polymorphisms (SNPs) of this region (TNF-alpha -308 G >...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17594690
DOI: 10.1002/ijc.22922

Genes

LTA
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17594690-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The 8.1 ancestral MHC haplotype is strongly associated with colorectal cancer risk.PMID 17594690Read ↗

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Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype: effect of multiple gene interactions.Semantic proximity Read ↗

A conserved linkage group on chromosome 6, the 8.1 ancestral haplotype, is a predisposing factor of chronic rhinosinusitis associated with nasal polyposis in aspirin-sensitive Hungarians.Semantic proximity Read ↗

Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype: a genetically determined defect of C4 influences immunological parameters of healthy carriers of the haplotype.Semantic proximity Read ↗

Genetic control of immune response in carriers of the 8.1 ancestral haplotype: correlation with levels of IgG subclasses: its relevance in the pathogenesis of autoimmune diseases.Semantic proximity Read ↗

Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer.Semantic proximity Read ↗

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