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Article

A dilated cardiomyopathy mutation blunts adrenergic response and induces contractile dysfunction under chronic angiotensin II stress.

American journal of physiology. Heart and circulatory physiology - 1 Dec 2015

Wilkinson Ross, Song Weihua, Smoktunowicz Natalia, Marston Steven

Abstract excerpt

We investigated cardiac contractility in the ACTC E361G transgenic mouse model of dilated cardiomyopathy (DCM). No differences in cardiac dimensions or systolic function were observed in young mice, whereas young adult mice exhibited only mild diastolic abnormalities. Dobutamine had an inotropic and lusitropic effect on the mouse heart. In papillary muscle at 37°C, dobutamine increased relaxation rates [∼50%...

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Source

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Identifiers

PMID: 26432839
DOI: 10.1152/ajpheart.00327.2015
PMCID: PMC4698377

Genes

ANG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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