Article
Angiotensin II-mediated phenotypic cardiomyocyte remodeling leads to age-dependent cardiac dysfunction and failure.
Hypertension (Dallas, Tex. : 1979) - 1 Aug 2005
Domenighetti Andrea A, Wang Qing, Egger Marcel, Richards Stephen M, Pedrazzini Thierry, Delbridge Lea M D
Abstract excerpt
Chronic elevation of plasma angiotensin II (Ang II) is detrimental to the heart. In addition to its hemodynamic effects, Ang II exerts cardiotrophic actions that contribute to cardiomyocyte remodeling. However, it remains to be clarified whether these direct actions of Ang II are sufficient to cause contractile dysfunction and heart failure in the absence of altered hemodynamic conditions. In this study, we used...
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