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Investigation of a transgenic mouse model of familial dilated cardiomyopathy.

Journal of molecular and cellular cardiology - 1 Sept 2010

Song Weihua, Dyer Emma, Stuckey Daniel, Leung Man-Ching, Memo Massimiliano, Mansfield Catherine, Ferenczi Michael, Liu Ke, Redwood Charles, Nowak Kristen, Harding Sian, Clarke Kieran, Wells Dominic, Marston Steven

Abstract excerpt

We have investigated a transgenic mouse model of inherited dilated cardiomyopathy that stably expresses the ACTC E361G mutation at around 50% of total actin in the heart. F-actin isolated from ACTC E361G mouse hearts was incorporated into thin filaments with native human tropomyosin and troponin and compared with NTG mouse actin by in vitro motility assay. There was no significant difference in sliding speed,...

Topics

Actins
Animals
Cardiomyopathy, Dilated
Disease Models, Animal
Heart
Humans
Mice
Mice, Transgenic
Mutation
Phenotype
Tropomyosin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Troponin

Source

Identifiers

PMID: 20600154
DOI: 10.1016/j.yjmcc.2010.05.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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