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Article

In Vivo Analysis of Troponin C Knock-In (A8V) Mice: Evidence that TNNC1 Is a Hypertrophic Cardiomyopathy Susceptibility Gene.

Circulation. Cardiovascular genetics - 1 Oct 2015

Martins Adriano S, Parvatiyar Michelle S, Feng Han-Zhong, Bos J Martijn, Gonzalez-Martinez David, Vukmirovic Milica, Turna Rajdeep S, Sanchez-Gonzalez Marcos A, Badger Crystal-Dawn, Zorio Diego A R, Singh Rakesh K, Wang Yingcai, Jin J-P, Ackerman Michael J, Pinto Jose R

Abstract excerpt

BACKGROUND: Mutations in thin-filament proteins have been linked to hypertrophic cardiomyopathy, but it has never been demonstrated that variants identified in the TNNC1 (gene encoding troponin C) can evoke cardiac remodeling in vivo. The goal of this study was to determine whether TNNC1 can be categorized as an hypertrophic cardiomyopathy susceptibility gene, such that a mouse model can recapitulate the clinical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26304555
DOI: 10.1161/CIRCGENETICS.114.000957
PMCID: PMC4618104

Genes

TNNC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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