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Article

Mouse Models of Cardiomyopathies Caused by Mutations in Troponin C.

International journal of molecular sciences - 2 Aug 2023

Tikunova Svetlana B, Thuma Jenna, Davis Jonathan P

Abstract excerpt

Cardiac muscle contraction is regulated via Ca2+ exchange with the hetero-trimeric troponin complex located on the thin filament. Binding of Ca2+ to cardiac troponin C, a Ca2+ sensing subunit within the troponin complex, results in a series of conformational re-arrangements among the thin filament components, leading to an increase in the formation of actomyosin cross-bridges and muscle contraction. Ultimately, a...

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Identifiers

PMID: 37569724
DOI: 10.3390/ijms241512349
PMCID: PMC10419064

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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