Article
Impaired cardiomyocyte relaxation and diastolic function in transgenic mice expressing slow skeletal troponin I in the heart.
The Journal of physiology - 15 May 1999
Fentzke R C, Buck S H, Patel J R, Lin H, Wolska B M, Stojanovic M O, Martin A F, Solaro R J, Moss R L, Leiden J M
Abstract excerpt
1. To assess the specific functions of the cardiac isoform of troponin I (cTnI), we produced transgenic mice that expressed slow skeletal troponin I (ssTnI) specifically in cardiomyocytes. Cardiomyocytes from these mice displayed quantitative replacement of cTnI with transgene-encoded ssTnI. 2. The ssTnI transgenic mice were viable and fertile and did not display increased mortality or detectable cardiovascular...
Topics
- Animals
- Calcium
- Cyclic AMP-Dependent Protein Kinases
- Diastole
- Gene Expression
- Heart
- Intracellular Fluid
- Isoproterenol
- Mice
- Mice, Transgenic
- Muscle, Skeletal
- Myocardial Contraction
- Myocardium