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Article

Differential effect of troponin T mutations on the inotropic responsiveness of mouse hearts--role of myofilament Ca2+ sensitivity increase.

The Journal of physiology - 15 Aug 2006

Sirenko Syevda G, Potter James D, Knollmann Björn C

Abstract excerpt

Troponin T (TnT) mutations that cause familial hypertrophic cardiomyopathy (FHC) and sudden cardiac death frequently increase myofilament Ca2+ sensitivity, suggesting that their Ca2+-sensitizing effect contributes importantly to the FHC pathogenesis. To test this hypothesis, we compared transgenic mice expressing the Ca2+-sensitizing TnT-I79N mutant (I79N), which causes a high rate of sudden cardiac death in...

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Identifiers

PMID: 16777946
DOI: 10.1113/jphysiol.2006.107557
PMCID: PMC1819413

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