Article
Hypertrophy, fibrosis, and sudden cardiac death in response to pathological stimuli in mice with mutations in cardiac troponin T.
Circulation - 12 Oct 2004
Maass Alexander H, Ikeda Kaori, Oberdorf-Maass Silke, Maier Sebastian K G, Leinwand Leslie A
Abstract excerpt
BACKGROUND: Transgenic mouse models expressing a missense mutation (R92Q) or a splice donor site mutation (trunc) in the cardiac troponin T (cTnT) model familial hypertrophic cardiomyopathy (FHC) in humans. Although males from these strains share the unusual property of having significantly small...
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