KIR gene content imputation from single-nucleotide polymorphisms in the Finnish population.

doi:10.7717/peerj.12692

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Article

KIR gene content imputation from single-nucleotide polymorphisms in the Finnish population.

PeerJ - 1 Jan 2022

Ritari Jarmo, Hyvärinen Kati, Partanen Jukka, Koskela Satu

Abstract excerpt

The killer cell immunoglobulin-like receptor (KIR) gene cluster on chromosome 19 encodes cell surface glycoproteins that bind class I human leukocyte antigen (HLA) molecules as well as some other ligands. Through regulation of natural killer (NK) cell activity KIRs participate in tumour surveillance and clearing viral infections. KIR gene gene copy number variation associates with the outcome of transplantations...

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PMID: 35036093
DOI: 10.7717/peerj.12692
PMCID: PMC8744484

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