Article
Kinetochore attachments require an interaction between unstructured tails on microtubules and Ndc80(Hec1).
Current biology : CB - 25 Nov 2008
Miller Stephanie A, Johnson Michael L, Stukenberg P Todd
Abstract excerpt
Kinetochore attachments to microtubules are tight enough to move chromosomes, yet the microtubules' plus ends must remain dynamic and reposition within the attachment pocket during depolymerization-coupled movement. Kinetochores are unable to bind microtubules after any of the four subunits of the Ndc80 complex are knocked down [2, 4]; however, because the Ndc80 complex has important structural roles [1-3], it is...
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