Article
Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population.
BMC genetics - 1 Oct 2015
Yang Wen-Yi, Petit Thibault, Thijs Lutgarde, Zhang Zhen-Yu, Jacobs Lotte, Hara Azusa, Wei Fang-Fei, Salvi Erika, Citterio Lorena, Delli Carpini Simona, Gu Yu-Mei, Knez Judita, Cauwenberghs Nicholas, Barcella Matteo, Barlassina Cristina, Manunta Paolo, Coppiello Giulia, Aranguren Xabier L, Kuznetsova Tatiana, Cusi Daniele, Verhamme Peter, Luttun Aernout, Staessen Jan A
Abstract excerpt
BACKGROUND: In mice MEOX2/TCF15 heterodimers are highly expressed in heart endothelial cells and are involved in the transcriptional regulation of lipid transport. In a general population, we investigated whether genetic variation in these genes predicted coronary heart disease (CHD). RESULTS: In 2027 participants randomly recruited from a Flemish population (51.0 % women; mean age 43.6 years), we genotyped six...
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