Article
Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure.
PLoS genetics - 1 May 2016
Smith J Gustav, Felix Janine F, Morrison Alanna C, Kalogeropoulos Andreas, Trompet Stella, Wilk Jemma B, Gidlöf Olof, Wang Xinchen, Morley Michael, Mendelson Michael, Joehanes Roby, Ligthart Symen, Shan Xiaoyin, Bis Joshua C, Wang Ying A, Sjögren Marketa, Ngwa Julius, Brandimarto Jeffrey, Stott David J, Aguilar David, Rice Kenneth M, Sesso Howard D, Demissie Serkalem, Buckley Brendan M, Taylor Kent D, Ford Ian, Yao Chen, Liu Chunyu, Sotoodehnia Nona, van der Harst Pim, Stricker Bruno H Ch, Kritchevsky Stephen B, Liu Yongmei, Gaziano J Michael, Hofman Albert, Moravec Christine S, Uitterlinden André G, Kellis Manolis, van Meurs Joyce B, Margulies Kenneth B, Dehghan Abbas, Levy Daniel, Olde Björn, Psaty Bruce M, Cupples L Adrienne, Jukema J Wouter, Djousse Luc, Franco Oscar H, Boerwinkle Eric, Boyer Laurie A, Newton-Cheh Christopher, Butler Javed, Vasan Ramachandran S, Cappola Thomas P, Smith Nicholas L
Abstract excerpt
Failure of the human heart to maintain sufficient output of blood for the demands of the body, heart failure, is a common condition with high mortality even with modern therapeutic alternatives. To identify molecular determinants of mortality in patients with new-onset heart failure, we performed a meta-analysis of genome-wide association studies and follow-up genotyping in independent populations. We identified...
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