Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

No association of two functional polymorphisms in human ALOX15 with myocardial infarction.

Atherosclerosis - 1 Jul 2009

Hersberger Martin, Müller Martina, Marti-Jaun Jacqueline, Heid Iris M, Coassin Stefan, Young Thomas F, Waechter Vanessa, Hengstenberg Christian, Meisinger Christine, Peters Annette, König Wolfgang, Holmer Stephan, Schunkert Heribert, Klopp Norman, Kronenberg Florian, Illig Thomas

Abstract excerpt

The 12/15-lipoxygenase plays a janus-role in inflammation with pro-inflammatory and anti-inflammatory effects in cell systems and even opposite effects on atherosclerosis in two different animal species. Screening of the human 15-lipoxygenase (ALOX15) gene detected a polymorphic C to T substitution at position c.-292, which led to three times higher ALOX15 activity in macrophages and showed a trend to be...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arachidonate 15-Lipoxygenase
Share to C-Reactive Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cohort Studies

Share to Haplotypes

Share to Inflammation

Share to Macrophages

Share to Myocardial Infarction

Share to Thrombosis

Source

Identifiers

PMID: 19131063
DOI: 10.1016/j.atherosclerosis.2008.11.017

Genes

ALOX15
CAD
CRP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No association of two functional polymorphisms in human ALOX15 with myocardial infarction.PMID 19131063Read ↗

Association of polymorphisms in the ALOX15B gene with coronary artery disease.Semantic proximity Read ↗

Two single nucleotide polymorphisms in ALOX15 are associated with risk of coronary artery disease in a Chinese Han population.Semantic proximity Read ↗

A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease.Semantic proximity Read ↗

Interaction between ALOX15 polymorphisms and coronary artery disease in North Indian population.Semantic proximity Read ↗

15-Lipoxygenase gene variants are associated with carotid plaque but not carotid intima-media thickness.Semantic proximity Read ↗

ASSOCIATION BETWEEN SINGLE POLYMORPHISM IN THE LOCUS RS17216473 OF THE GENE THAT ENCODES 5-LIPOXYGENASE-ACTIVATING PROTEIN AND RISK OF MYOCARDIAL INFARCTION.Semantic proximity Read ↗

Common Polymorphisms in the 5-Lipoxygenase Pathway and Risk of Incident Myocardial Infarction: A Danish Case-Cohort Study.Semantic proximity Read ↗

Coronary risk in relation to genetic variation in MEOX2 and TCF15 in a Flemish population.Semantic proximity Read ↗

The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke.Semantic proximity Read ↗

Genetic variants of arachidonate 5-lipoxygenase-activating protein, and risk of incident myocardial infarction and ischemic stroke: a nested case-control approach.Semantic proximity Read ↗

Association of ALOX15 gene polymorphism with ischemic stroke in Northern Chinese Han population.Semantic proximity Read ↗

Functional polymorphism in ALOX15 results in increased allele-specific transcription in macrophages through binding of the transcription factor SPI1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.