Article
Association of the Trp719Arg polymorphism in kinesin-like protein 6 with myocardial infarction and coronary heart disease in 2 prospective trials: the CARE and WOSCOPS trials.
Journal of the American College of Cardiology - 29 Jan 2008
Iakoubova Olga A, Tong Carmen H, Rowland Charles M, Kirchgessner Todd G, Young Bradford A, Arellano Andre R, Shiffman Dov, Sabatine Marc S, Campos Hannia, Packard Christopher J, Pfeffer Marc A, White Thomas J, Braunwald Eugene, Shepherd James, Devlin James J, Sacks Frank M
Abstract excerpt
OBJECTIVES: We asked whether 35 genetic polymorphisms, previously found to be associated with cardiovascular disease, were associated with myocardial infarction (MI) in the CARE (Cholesterol and Recurrent Events) trial and with coronary heart disease (CHD) in the WOSCOPS (West of Scotland Coronary Prevention Study) trial and whether the risk associated with these polymorphisms could be reduced by pravastatin...
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