Article
Complex effects of sequence variants on lipid levels and coronary artery disease.
Cell - 14 Sept 2023
Snaebjarnarson Audunn S, Helgadottir Anna, Arnadottir Gudny A, Ivarsdottir Erna V, Thorleifsson Gudmar, Ferkingstad Egil, Einarsson Gudmundur, Sveinbjornsson Gardar, Thorgeirsson Thorgeir E, Ulfarsson Magnus O, Halldorsson Bjarni V, Olafsson Isleifur, Erikstrup Christian, Pedersen Ole B, Nyegaard Mette, Bruun Mie T, Ullum Henrik, Brunak Søren, Iversen Kasper Karmark, Christensen Alex Hoerby, Olesen Morten S, Ghouse Jonas, Banasik Karina, Knowlton Kirk U, Arnar David O, Thorgeirsson Gudmundur, Nadauld Lincoln, Ostrowski Sisse Rye, Bundgaard Henning, Holm Hilma, Sulem Patrick, Stefansson Kari, Gudbjartsson Daniel F
Abstract excerpt
Many sequence variants have additive effects on blood lipid levels and, through that, on the risk of coronary artery disease (CAD). We show that variants also have non-additive effects and interact to affect lipid levels as well as affecting variance and correlations. Variance and correlation effects are often signatures of epistasis or gene-environmental interactions. These complex effects can translate into CAD...
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