Article
Curious Dichotomies of Apolipoprotein E Function in Alzheimer’s Disease and Cancer—One Explanatory Mechanism of Inverse Disease Associations?
2025-02-26
Abstract excerpt
An apparent "inverse" relationship exists between two seemingly unconnected conditions: Alzheimer's disease (AD) and cancer, despite sharing similar risk factors, like increased age and obesity. AD is associated with amyloid beta (Aβ) plaques and neurofibrillary tau tangles that cause neural degeneration; cancer, in contrast, is characterised by enhanced cell survival and proliferation. Apolipoprotein E (ApoE...
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Identifiers and source
- Literature Corpus work
- 4a324da5-d648-5ffd-9a42-adbbbd7066bd
- DOI
- 10.20944/preprints202502.2073.v1