Article
CHRFAM7A: A human specific fusion gene, accounts for the translational gap for cholinergic strategies in Alzheimer's disease.
EBioMedicine - 1 Sept 2020
Szigeti Kinga, Ihnatovych Ivanna, Birkaya Barbara, Chen Ziqiang, Ouf Aya, Indurthi Dinesh C, Bard Jonathan E, Kann Julien, Adams Alexandrea, Chaves Lee, Sule Norbert, Reisch Joan S, Pavlik Valory, Benedict Ralph H B, Auerbach Anthony, Wilding Gregory
Abstract excerpt
BACKGROUND: Cholinergic neuronal loss is one of the hallmarks of AD related neurodegeneration; however, preclinical promise of α7 nAChR drugs failed to translate into humans. CHRFAM7A, a uniquely human fusion gene, is a negative regulator of α7 nAChR and was unaccounted for in preclinical models. METHODS: Molecular methods: Function of CHRFAM7A alleles was studied in vitro in two disease relevant phenotypic...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.