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Article

Genetic variation in CHRNA7 and CHRFAM7A is associated with nicotine dependence and response to varenicline treatment.

European journal of human genetics : EJHG - 1 Dec 2018

Cameli Cinzia, Bacchelli Elena, De Paola Maria, Giucastro Giuliano, Cifiello Stefano, Collo Ginetta, Cainazzo Maria Michela, Pini Luigi Alberto, Maestrini Elena, Zoli Michele

Abstract excerpt

The role of nicotinic acetylcholine receptors (nAChR) in nicotine dependence (ND) is well established; CHRNA7, encoding the α7 subunit, has a still uncertain role in ND, although it is implicated in a wide range of neuropsychiatric conditions. CHRFAM7A, a hybrid gene containing a partial duplication of CHRNA7, is possibly involved in modulating α7 nAChR function. The aim of this study was to investigate the role...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 30089821
DOI: 10.1038/s41431-018-0223-2
PMCID: PMC6244195

Genes

CHRNA7
CPD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic variation in CHRNA7 and CHRFAM7A is associated with nicotine dependence and response to varenicline treatment.PMID 30089821Read ↗

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