Unanswered questions in the regulation and function of the duplicated α7 nicotinic receptor gene CHRFAM7A.

doi:10.1016/j.phrs.2023.106783

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Article

Unanswered questions in the regulation and function of the duplicated α7 nicotinic receptor gene CHRFAM7A.

Pharmacological research - 1 Jun 2023

Leonard Sherry, Benfante Roberta

Abstract excerpt

The α7 nicotinic receptor (α7 nAChR) is an important entry point for Ca2+ into the cell, which has broad and important effects on gene expression and function. The gene (CHRNA7), mapping to chromosome (15q14), has been genetically linked to a large number of diseases, many of which involve defects in cognition. While numerous mutations in CHRNA7 are associated with mental illness and inflammation, an important...

Topics

Humans
DNA Copy Number Variations
alpha7 Nicotinic Acetylcholine Receptor
Mental Disorders
Cognition
Mutation
Receptors, Nicotinic

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PMID: 37164281
DOI: 10.1016/j.phrs.2023.106783

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