Article
Frequent DPH3 promoter mutations in skin cancers.
Oncotarget - 3 Nov 2015
Denisova Evgeniya, Heidenreich Barbara, Nagore Eduardo, Rachakonda P Sivaramakrishna, Hosen Ismail, Akrap Ivana, Traves Víctor, García-Casado Zaida, López-Guerrero José Antonio, Requena Celia, Sanmartin Onofre, Serra-Guillén Carlos, Llombart Beatriz, Guillén Carlos, Ferrando Jose, Gimeno Enrique, Nordheim Alfred, Hemminki Kari, Kumar Rajiv
Abstract excerpt
Recent reports suggested frequent occurrence of cancer associated somatic mutations within regulatory elements of the genome. Based on initial exome sequencing of 21 melanomas, we report frequent somatic mutations in skin cancers in a bidirectional promoter of diphthamide biosynthesis 3 (DPH3) and oxidoreductase NAD-binding domain containing 1 (OXNAD1) genes. The UV-signature mutations occurred at sites adjacent...
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