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Article

Hypermutation of DPYD Deregulates Pyrimidine Metabolism and Promotes Malignant Progression.

Molecular cancer research : MCR - 1 Feb 2016

Edwards Lauren, Gupta Rohit, Filipp Fabian Volker

Abstract excerpt

UNLABELLED: New strategies are needed to diagnose and target human melanoma. To this end, genomic analyses was performed to assess somatic mutations and gene expression signatures using a large cohort of human skin cutaneous melanoma (SKCM) patients from The Cancer Genome Atlas (TCGA) project to identify critical differences between primary and metastatic tumors. Interestingly, pyrimidine metabolism is one of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26609109
DOI: 10.1158/1541-7786.MCR-15-0403
PMCID: PMC5024535

Genes

DPYD
CAD
CANT1
DPYS
ENTPD1
NME6
POLE
POLQ
PRIM2
UPP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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