Article
SDHD promoter mutations are rare events in cutaneous melanomas but SDHD protein expression is downregulated in advanced cutaneous melanoma.
PloS one - 1 Jan 2017
Pópulo Helena, Batista Rui, Sampaio Cristina, Pardal Joana, Lopes José Manuel, Soares Paula
Abstract excerpt
BACKGROUND: SDHD promoter mutations were reported in 4-10% of cutaneous melanomas. The advanced clinico-pathological and patient survival association with SDHD mutation and/or expression in cutaneous melanoma remains controversial. OBJECTIVES: To evaluate the presence of SDHD promoter mutations and SDHD protein expression in a melanoma series and its possible association with prognosis and survival of the...
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