Article
Analysis of SDHD promoter mutations in various types of melanoma.
Oncotarget - 22 Sept 2015
Scholz Simone L, Horn Susanne, Murali Rajmohan, Möller Inga, Sucker Antje, Sondermann Wiebke, Stiller Mathias, Schilling Bastian, Livingstone Elisabeth, Zimmer Lisa, Reis Henning, Metz Claudia H, Zeschnigk Michael, Paschen Annette, Steuhl Klaus-Peter, Schadendorf Dirk, Westekemper Henrike, Griewank Klaus G
Abstract excerpt
OBJECTIVES: Recently, recurrent mutations in regulatory DNA regions, such as promoter mutations in the TERT gene were identified in melanoma. Subsequently, Weinhold et al. reported SDHD promoter mutations occurring in 10% of melanomas and being associated with a lower overall survival rate. Our study analyzes the mutation rate and clinico-pathologic associations of SDHD promoter mutations in a large cohort of...
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