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Article

NACA deficiency reveals the crucial role of somite-derived stromal cells in haematopoietic niche formation.

Nature communications - 28 Sept 2015

Murayama Emi, Sarris Milka, Redd Michael, Le Guyader Dorothée, Vivier Catherine, Horsley Wyatt, Trede Nikolaus, Herbomel Philippe

Abstract excerpt

The ontogeny of haematopoietic niches in vertebrates is essentially unknown. Here we show that the stromal cells of the caudal haematopoietic tissue (CHT), the first niche where definitive haematopoietic stem/progenitor cells (HSPCs) home in zebrafish development, derive from the caudal somites through an epithelial-mesenchymal transition (EMT). The resulting stromal cell progenitors accompany the formation of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26411530
DOI: 10.1038/ncomms9375

Genes

NACA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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