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Article

Cebpa is required for haematopoietic stem and progenitor cell generation and maintenance in zebrafish.

Open biology - 1 Nov 2024

Chen Kemin, Wu Jieyi, Zhang Yuxian, Liu Wei, Chen Xiaohui, Zhang Wenqing, Huang Zhibin

Abstract excerpt

The CCAAT enhancer binding protein alpha (CEBPA) is crucial for myeloid differentiation and the balance of haematopoietic stem and progenitor cell (HSPC) quiescence and self-renewal, and its dysfunction can drive leukemogenesis. However, its role in HSPC generation has not been fully elucidated. Here, we utilized various zebrafish cebpa mutants to investigate the function of Cebpa in the HSPC compartment....

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Share to CCAAT-Enhancer-Binding Proteins
Share to Core Binding Factor Alpha 2 Subunit

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Hematopoiesis

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Source

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Identifiers

PMID: 39500381
DOI: 10.1098/rsob.240215
PMCID: PMC11537755

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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