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Article

Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos

29 Oct 2009

Abstract excerpt

Metastasis-associated antigens 1/2/3 (Mta1/2/3) are components of nucleosome remodeling and deacetylase (NuRD) complexes and have been found to play roles in embryonic development and homeostasis. However, their functions in primitive hematopoiesis are unknown. In this study, we demonstrate that knockdown of mta3 by antisense morpholinos abolishes primitive hematopoietic lineages and causes abnormal angiogenesis...

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PMID: 19864643
DOI: 10.1182/blood-2009-06-227777

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