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Article

Tango6 regulates HSPC proliferation and definitive haematopoiesis via Ikzf1 and Cmyb in caudal haematopoietic tissue.

Development (Cambridge, England) - 1 Jan 2025

Liu Shengnan, Feng Zhi, Su Ming, Liu Chenchen, Xi Yuan, Chen Huan, Luo Lingfei, Tian Xin, Zhao Fangying, Li Li

Abstract excerpt

Haematopoietic stem and progenitor cells (HSPCs) arise from the aorta-gonad-mesonephros and migrate to the caudal haematopoietic tissue (CHT) in zebrafish, where nascent HSPCs undergo tightly controlled proliferation and differentiation to promote definitive haematopoiesis. Effective expansion of HSPCs requires the coordination of well-established vesicle trafficking systems and appropriate transcription factors....

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PMID: 39620979
DOI: 10.1242/dev.202903

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