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Article

The core-binding factor beta subunit is required for bone formation and hematopoietic maturation.

Nature genetics - 1 Dec 2002

Miller Janelle, Horner Alan, Stacy Terryl, Lowrey Christopher, Lian Jane B, Stein Gary, Nuckolls Glen H, Speck Nancy A

Abstract excerpt

Core-binding factor beta (Cbfbeta) is the common non-DNA-binding subunit of the Cbf family of heterodimeric transcription factors. Mice deficient in Cbfbeta have a severe block in fetal liver hematopoiesis at the stage of hematopoietic stem cell (HSC) emergence. Here we show that by providing Cbf...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12434155
DOI: 10.1038/ng1049

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12434155-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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The core-binding factor beta subunit is required for bone formation and hematopoietic maturation.PMID 12434155Read ↗

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