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Article

Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-2.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2015

Funami Kenji, Matsumoto Misako, Enokizono Yoshiaki, Ishii Noriko, Tatematsu Megumi, Oshiumi Hiroyuki, Inagaki Fuyuhiko, Seya Tsukasa

Abstract excerpt

TLR4 triggers LPS signaling through the adaptors Toll/IL-1R domain-containing adaptor molecule (TICAM)-2 (also called TRAM) and TICAM-1 (also called TRIF), together with Toll/IL-1R domain-containing adaptor protein (TIRAP) and MyD88. The MyD88 pathway mediates early phase responses to LPS on the plasma membrane, whereas the TICAM pathway mediates late-phase responses, which induce the production of type I IFN and...

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Share to Adaptor Proteins, Vesicular Transport
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interferon Regulatory Factor-3

Share to Interferon Type I

Share to Lipopolysaccharides

Share to Microscopy, Confocal

Share to Myeloid Differentiation Factor 88

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Source

Identifiers

PMID: 26408662
DOI: 10.4049/jimmunol.1402628

Genes

TLR4
TIRAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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