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ILT7 activation and plasmacytoid dendritic cell response are governed by BST2 determinants that are structurally-distinct

2019-02-21

Abstract excerpt

The interaction of the human pDC receptor ILT7 with its ligand, BST2, significantly regulates pDC’s TLR-induced innate immune responses. This interaction has critical biological consequences, yet, its structural requirements are not fully characterized. The BST2 ectodomain can be divided in structurally and functionally distinct regions; while the coiled-coil region contains a newly-defined ILT7 binding surface, t...

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Literature Corpus work
2076b966-5d4b-5a76-9dca-3efc55541baf
DOI
10.1101/557116
Open publication

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ILT7 activation and plasmacytoid dendritic cell response are governed by BST2 determinants that are structurally-distinctDOI 10.1101/557116
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