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Article

TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88.

PloS one - 1 Jan 2012

Ohnishi Hidenori, Tochio Hidehito, Kato Zenichiro, Kawamoto Norio, Kimura Takeshi, Kubota Kazuo, Yamamoto Takahiro, Funasaka Tatsuyoshi, Nakano Hiroshi, Wong Richard W, Shirakawa Masahiro, Kondo Naomi

Abstract excerpt

MyD88, a Toll/interleukin-1 receptor homology (TIR) domain-containing adaptor protein, mediates signals from the Toll-like receptors (TLR) or IL-1/IL-18 receptors to downstream kinases. In MyD88-dependent TLR4 signaling, the function of MyD88 is enhanced by another TIR domain-containing adaptor,...

Read the complete abstract on PubMed

Topics

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Share to Immunoprecipitation
Share to Interleukin-12
Share to Interleukin-18

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Microscopy, Confocal

Share to Myeloid Differentiation Factor 88

Share to Receptors, Interleukin-1

Share to Th1 Cells

Share to Toll-Like Receptor 4

Source

Open in PubMed Open full text

Identifiers

PMID: 22685567
DOI: 10.1371/journal.pone.0038423
PMCID: PMC3369926

Genes

TLR4
TIRAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22685567-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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