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Article

TLR2 & Co: a critical analysis of the complex interactions between TLR2 and coreceptors.

Journal of leukocyte biology - 1 Nov 2013

van Bergenhenegouwen Jeroen, Plantinga Theo S, Joosten Leo A B, Netea Mihai G, Folkerts Gert, Kraneveld Aletta D, Garssen Johan, Vos Arjan P

Abstract excerpt

TLRs play a major role in microbe-host interactions and innate immunity. Of the 10 functional TLRs described in humans, TLR2 is unique in its requirement to form heterodimers with TLR1 or TLR6 for the initiation of signaling and cellular activation. The ligand specificity of TLR2 heterodimers has been studied extensively, using specific bacterial and synthetic lipoproteins to gain insight into the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23990624
DOI: 10.1189/jlb.0113003

Genes

TLR2
TLR1
TLR6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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