Article
Examining the statistical properties of fine-scale mapping in large-scale association studies.
Genetic epidemiology - 1 Apr 2008
Wiltshire Steven, Morris Andrew P, Zeggini Eleftheria
Abstract excerpt
Interpretation of dense single nucleotide polymorphism (SNP) follow-up of genome-wide association or linkage scan signals can be facilitated by establishing expectation for the behaviour of primary mapping signals upon fine-mapping, under both null and alternative hypotheses. We examined the inferences that can be made regarding the posterior probability of a real genetic effect and considered different...
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