Article
Quantifying the mapping precision of genome-wide association studies using whole-genome sequencing data.
Genome biology - 16 May 2017
Wu Yang, Zheng Zhili, Visscher Peter M, Yang Jian
Abstract excerpt
BACKGROUND: Understanding the mapping precision of genome-wide association studies (GWAS), that is the physical distances between the top associated single-nucleotide polymorphisms (SNPs) and the causal variants, is essential to design fine-mapping experiments for complex traits and diseases. RESULTS: Using simulations based on whole-genome sequencing (WGS) data from 3642 unrelated individuals of European...
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