Article
Genetic Variation in the Platelet Endothelial Aggregation Receptor 1 Gene Results in Endothelial Dysfunction.
PloS one - 1 Jan 2015
Fisch Adam S, Yerges-Armstrong Laura M, Backman Joshua D, Wang Hong, Donnelly Patrick, Ryan Kathleen A, Parihar Ankita, Pavlovich Mary A, Mitchell Braxton D, O'Connell Jeffrey R, Herzog William, Harman Christopher R, Wren Jonathan D, Lewis Joshua P
Abstract excerpt
Platelet Endothelial Aggregation Receptor 1 (PEAR1) is a newly identified membrane protein reported to be involved in multiple vascular and thrombotic processes. While most studies to date have focused on the effects of this receptor in platelets, PEAR1 is located in multiple tissues including the endothelium, where it is most highly expressed. Our first objective was to evaluate the role of PEAR1 in endothelial...
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