Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted deep resequencing identifies coding variants in the PEAR1 gene that play a role in platelet aggregation.

PloS one - 1 Jan 2013

Kim Yoonhee, Suktitipat Bhoom, Yanek Lisa R, Faraday Nauder, Wilson Alexander F, Becker Diane M, Becker Lewis C, Mathias Rasika A

Abstract excerpt

Platelet aggregation is heritable, and genome-wide association studies have detected strong associations with a common intronic variant of the platelet endothelial aggregation receptor1 (PEAR1) gene both in African American and European American individuals. In this study, we used a sequencing approach to identify additional exonic variants in PEAR1 that may also determine variability in platelet aggregation in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Cohort Studies

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Linkage Disequilibrium

Share to Open Reading Frames

Share to Polymorphism, Single Nucleotide

Share to White People

Source

Open in PubMed Open full text

Identifiers

PMID: 23704978
DOI: 10.1371/journal.pone.0064179
PMCID: PMC3660448

Genes

PEAR1
MAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted deep resequencing identifies coding variants in the PEAR1 gene that play a role in platelet aggregation.PMID 23704978Read ↗

Identification of a specific intronic PEAR1 gene variant associated with greater platelet aggregability and protein expression.Semantic proximity Read ↗

Genetic Variation in the Platelet Endothelial Aggregation Receptor 1 Gene Results in Endothelial Dysfunction.Semantic proximity Read ↗

A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability.Semantic proximity Read ↗

Genome-wide association study of platelet aggregation in African Americans.Semantic proximity Read ↗

Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes.Semantic proximity Read ↗

Whole exome sequencing in the Framingham Heart Study identifies rare variation in HYAL2 that influences platelet aggregation.Semantic proximity Read ↗

Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.Semantic proximity Read ↗

Genetic Variants of PEAR1 are Associated with Platelet Function and Antiplatelet Drug Efficacy: A Systematic Review and Meta-Analysis.Semantic proximity Read ↗

A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways.Semantic proximity Read ↗

Prospective Evaluation of Genetic Variation in Platelet Endothelial Aggregation Receptor 1 Reveals Aspirin-Dependent Effects on Platelet Aggregation Pathways.Semantic proximity Read ↗

Association of PEAR1 genetic variants with platelet reactivity in response to dual antiplatelet therapy with aspirin and clopidogrel in the Chinese patient population after percutaneous coronary intervention.Semantic proximity Read ↗

Variation of PEAR1 DNA methylation influences platelet and leukocyte functionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.