Article
Targeted deep resequencing identifies coding variants in the PEAR1 gene that play a role in platelet aggregation.
PloS one - 1 Jan 2013
Kim Yoonhee, Suktitipat Bhoom, Yanek Lisa R, Faraday Nauder, Wilson Alexander F, Becker Diane M, Becker Lewis C, Mathias Rasika A
Abstract excerpt
Platelet aggregation is heritable, and genome-wide association studies have detected strong associations with a common intronic variant of the platelet endothelial aggregation receptor1 (PEAR1) gene both in African American and European American individuals. In this study, we used a sequencing ap...
Topics
- Black or African American
- Alleles
- Cohort Studies
- Exons
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- High-Throughput Nucleotide Sequencing
- Humans
- Linkage Disequilibrium
- Male
- Middle Aged
- Open Reading Frames
- Platelet Aggregation