Article
Genome-wide association study of platelet aggregation in African Americans.
BMC genetics - 30 May 2015
Qayyum Rehan, Becker Lewis C, Becker Diane M, Faraday Nauder, Yanek Lisa R, Leal Suzanne M, Shaw Chad, Mathias Rasika, Suktitipat Bhoom, Bray Paul F
Abstract excerpt
BACKGROUND: We have previously shown that platelet aggregation has higher heritability in African Americans than European Americans. However, a genome-wide association study (GWAS) of platelet aggregation in African Americans has not been reported. We measured platelet aggregation in response to arachidonic acid, ADP, collagen, or epinephrine by optical aggregometry. The discovery cohort was 825 African Americans...
Topics
- Adenosine Diphosphate
- Adult
- Black or African American
- Alleles
- Arachidonic Acid
- Collagen
- Epinephrine
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genome-Wide Association Study