Article
A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability.
Arteriosclerosis, thrombosis, and vascular biology - 1 Aug 2008
Herrera-Galeano J Enrique, Becker Diane M, Wilson Alexander F, Yanek Lisa R, Bray Paul, Vaidya Dhananjay, Faraday Nauder, Becker Lewis C
Abstract excerpt
OBJECTIVE: Platelet endothelial aggregation receptor-1 (PEAR1) is a recently identified platelet transmembrane protein that becomes activated by platelet contact. We looked for novel genetic variants in PEAR1 and studied their association with agonist-induced native platelet aggregation and with the inhibitory effect of aspirin on platelets. METHODS AND RESULTS: We genotyped PEAR1 for 10 single nucleotide...
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