Article
Genetic variation in PEAR1 is associated with platelet aggregation and cardiovascular outcomes.
Circulation. Cardiovascular genetics - 1 Apr 2013
Lewis Joshua P, Ryan Kathleen, O'Connell Jeffrey R, Horenstein Richard B, Damcott Coleen M, Gibson Quince, Pollin Toni I, Mitchell Braxton D, Beitelshees Amber L, Pakzy Ruth, Tanner Keith, Parsa Afshin, Tantry Udaya S, Bliden Kevin P, Post Wendy S, Faraday Nauder, Herzog William, Gong Yan, Pepine Carl J, Johnson Julie A, Gurbel Paul A, Shuldiner Alan R
Abstract excerpt
BACKGROUND- Aspirin or dual antiplatelet therapy with aspirin and clopidogrel is a standard therapy for patients who are at increased risk for cardiovascular events. However, the genetic determinants of variable response to aspirin (alone and in combination with clopidogrel) are not known. METHODS AND RESULTS- We measured ex vivo platelet aggregation before and after dual antiplatelet therapy in individuals...
Topics
- Adult
- Aged
- Alleles
- Chromosomes, Human, Pair 1
- Clopidogrel
- Cohort Studies
- Coronary Artery Disease
- Female
- Genome-Wide Association Study