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Article

Whole exome sequencing in the Framingham Heart Study identifies rare variation in HYAL2 that influences platelet aggregation.

Thrombosis and haemostasis - 2 Jun 2017

Eicher John D, Chen Ming-Huei, Pitsillides Achilleas N, Lin Honghuang, Veeraraghavan Narayanan, Brody Jennifer A, Metcalf Ginger A, Muzny Donna M, Gibbs Richard A, Becker Diane M, Becker Lewis C, Faraday Nauder, Mathias Rasika A, Yanek Lisa R, Boerwinkle Eric, Cupples L Adrienne, Johnson Andrew D

Abstract excerpt

Inhibition of platelet reactivity is a common therapeutic strategy in secondary prevention of cardiovascular disease. Genetic and environmental factors influence inter-individual variation in platelet reactivity. Identifying genes that contribute to platelet reactivity can reveal new biological mechanisms and possible therapeutic targets. Here, we examined rare coding variation to identify genes associated with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28300864
DOI: 10.1160/TH16-09-0677
PMCID: PMC7472427

Genes

HYAL2
GPI
GSTZ1
MAPRE1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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