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Article

Variation of PEAR1 DNA methylation influences platelet and leukocyte function

29 Oct 2019

Abstract excerpt

BACKGROUND: Platelet-endothelial aggregation receptor 1 (PEAR-1) is a transmembrane receptor involved in platelet activation and megakaryopoiesis whose expression is driven by DNA methylation. PEAR1 variants were associated with differential platelet response to activation and cardiovascular outcomes. We aimed at investigating the link between PEAR1 methylation and platelet and leukocyte function markers in a...

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Share to Antiplatelet Therapy and Cardiovascular Diseases
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PMID: 31665082
DOI: 10.1186/s13148-019-0744-8

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