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Article

PEAR1 is not a major susceptibility gene for cardiovascular disease in a Flemish population.

BMC medical genetics - 27 Apr 2017

Yang Wen-Yi, Petit Thibault, Cauwenberghs Nicholas, Zhang Zhen-Yu, Sheng Chang-Sheng, Thijs Lutgarde, Salvi Erika, Izzi Benedetta, Vandenbriele Christophe, Wei Fang-Fei, Gu Yu-Mei, Jacobs Lotte, Citterio Lorena, Delli Carpini Simona, Barlassina Cristina, Cusi Daniele, Hoylaerts Marc F, Verhamme Peter, Kuznetsova Tatiana, Staessen Jan A

Abstract excerpt

BACKGROUND: Platelet Endothelial Aggregation Receptor 1 (PEAR1), a membrane protein highly expressed in platelets and endothelial cells, plays a role in platelet contact-induced activation, sustained platelet aggregation and endothelial function. Previous reports implicate PEAR1 rs12041331 as a variant influencing risk in patients with coronary heart disease. We investigated whether genetic variation in PEAR1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28449647
DOI: 10.1186/s12881-017-0411-x
PMCID: PMC5408434

Genes

PEAR1

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